Saturday, August 23, 2014

Understanding Your Genetic Structure in Relation to That of Your Siblings: Gene Tracking, A Pathway of the Future



Are the genes of siblings related? Understanding the genetic structure of siblings presents a challenge, as is comprehending your own genetic structure.

“Do my sister and I have the same genes? How can this be possible if the color of our eyes is different? We do look alike in some other ways.” 

In this particular instance, a young man wants to know if his genetic structure is identical to or different from that of his sister because other than the color of their eyes,  their photographs reveal other, distinct similarities in appearance. 

A basic explanation of genes, genotypes, gene structure and genetic mapping will help to answer his questions and some of yours. 

What are genes?

MedlinePlus offers some basic information about genes.

“A gene is a short piece of DNA, which tells the body how to build a specific protein. There are approximately 30,000 genes in each cell of the human body. The combination of all genes makes up the blueprint for the human body and its functions.”

What is a genotype?

“A person's genetic makeup is called a genotype.”

Discussing genetic structure further may help to answer more questions.

“Genes are located on strands of DNA, just like beads on a string. The DNA strands make up the chromosomes. Chromosomes contain matching pairs of one copy of a specific gene. The gene occurs in the same position on each chromosome.”

Chromosomes, like sex chromosomes that determine gender, come from the parents of siblings. For example,

“In females, one sex chromosome gets its gene from the mother; the other matching sex chromosome has the gene from the father. In males, a single X chromosome comes from the mother and a non-matching Y chromosome comes from the father.”

Genes control traits that are evident in siblings, for example, their eye color.

Dominant traits are controlled by one gene in the pair. Recessive traits require both genes in the pair to work together to control the trait.”

Thus, in siblings, including yours, there may be similarities or differences in eye color, but these traits are not inherited from each other or transferred in any way from one to the other. One sibling can inherit blue eyes, which is a dominant trait and the other brown eyes, as a recessive trait. For example, a male sibling may have blue eyes similar to those of his mother, while the female sibling has brown eyes similar to those of her father.

Note that genetic structure does not just involve the parents of siblings, as there are grandparents, great-grandparents, etc. many generations back, to consider. Like the siblings, each parent or grandparent is born with a unique, blue print that has specific, unique traits that siblings can inherit from their parents. Siblings do not necessarily inherit the same trait.  

Gene tracking enables one to follow genetic similarities and differences in genetic structure from generation to generation. On the other hand, genome mapping involves creating a genetic map that designates or assigns DNA to a specific chromosome. This is currently proving to be useful in terms of ongoing medical research. 

Genome mapping is a relatively new science open to further discovery with respect to anyone seriously interested in finding more answers related to the genetic structure of siblings or desiring to pursue the study of genetics further.

Siblings born of the same parents can have a similar genetic structure, but many questions remain unanswered with respect to the relationship of genetic structure in siblings.


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